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Abstract P623: Nutrient Stress Response of Cardiovascular Cells to {beta}-Blockers, ARB and AT2R Agonists Session Title: Receptors and Signal Transduction/Vascular Biology and Stiffness
To determine how cardioprotective drugs modulate cell response to nutrient starvation, we investigated the effects of β-blockers (Nebivolol [Neb], Carvedilol [Car], Metoprolol [Met] and Atenolol [Aten] (3μM each), Angiotensin II (Ang II) (300nM), AT1R blocker (ARB-Losartan (1μM)) and AT2R agonists (CGP42112A [CGP] and a novel peptide agonist NP-6A4 (300nM each)) on serum-starved HL-1 cardiomyocytes. The Xcelligence Real-Time Cell Analyzer (RTCA), which measures area covered by cells in microtiter plates and displays it as a unitless quantity called Cell Index (CI), was used to assess cellular changes in response...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Mahmood, A., Pulakat, L. Tags: Session Title: Receptors and Signal Transduction/Vascular Biology and Stiffness Source Type: research
Gumprecht shadows: when to use this terminology?
The expression Gumprecht shadows historically refers to lymphocyte lysates commonly observed in patients with chronic lymphocytic leukemia (CLL). A literature review revealed that this term is restricted to CLL cases, and should not be applied to lymphocytosis-related conditions. Inappropriate use of this term can cause great anxiety in individuals receiving their blood count results, as well as in their families. In a web search engine commonly used to clear doubts on medical terms, there are countless pages where Gumprecht shadows are associated with CLL.A locução sombras de Gumprecht refere-se, historicamente, aos lin...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - December 18, 2013 Category: Pathology Source Type: research
The role of cytogenetics and molecular biology in the diagnosis, treatment and monitoring of patients with chronic myeloid leukemia
ABSTRACT Chronic myeloid leukemia (CML) is the most common myeloproliferative disorder among chronic neoplasms. The history of this disease joins with the development of cytogenetic analysis techniques in human. CML was the first cancer to be associated with a recurrent chromosomal alteration, a reciprocal translocation between the long arms of chromosomes 9 and 22 - Philadelphia chromosome. This work is an updated review on CML, which highlights the importance of cytogenetics analysis in the continuous monitoring and therapeutic orientation of this disease. The search for scientific articles was carried out in the PubMed ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - June 7, 2018 Category: Pathology Source Type: research
Prevalence of Epstein-Barr Viral DNA among children at a single hospital in Suzhou, China
CONCLUSIONS: This is a large sample study that revealed the prevalence of plasma EBV-DNA levels in children of various ages and presenting illnesses.PMID:34174213 | DOI:10.1016/j.jped.2021.05.006
Source: Jornal de Pediatria - June 26, 2021 Category: Pediatrics Authors: Ting Shi Linlin Huang Jianmei Tian Source Type: research
cAMP Signaling Pathway Prevents Dasatinib-Induced Vascular Hyperpermeability
In this study, we investigated how dasatinib increase vascular permeability, and how it can be prevented. Cytotoxicity was observed in vascular endothelial cells or epithelial cells were exposed to high concentrations of dasatinib. Thus, it was observed in vascular endothelial cells such as human umbilical vascular endothelial cell (HUVEC). Vascular endothelial (VE)-cadherin is one of the important factors that control vascular permeability. When VE-cadherin expression decreases, vascular permeability increases, but it did not change with tyrosine kinase inhibitor exposure. Monolayer permeability significantly increased on...
Source: Biological and Pharmaceutical Bulletin - August 2, 2021 Category: Drugs & Pharmacology Authors: Tsuyoshi Aoyama Hiroki Kuriyama Yuki Sato Shungo Imai Hitoshi Kashiwagi Mitsuru Sugawara Yoh Takekuma Source Type: research
Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors
Conclusions:Fli1 governs vascular morphogenesis by regulating endothelial potential by inversely regulating endothelial versus myogenic programs in MPCs. Our data uncover an important and previously unrecognized mechanism of vascular morphogenesis governed by Fli1 and highlight the physiological significance of the fine tuning of Fli1 activity in multipotent progenitors for proper vascular and muscle morphogenesis during development and disease.PMID:34544261 | DOI:10.1161/CIRCRESAHA.121.318986
Source: Circulation Research - September 21, 2021 Category: Cardiology Authors: Anwarul Ferdous Sarvjeet Singh Yuxuan Luo Md J Abedin Nan Jiang Cameron E Perry Bret M Evers Thomas G Gillette Michael Kyba Maria Trojanowska Joseph A Hill Source Type: research
Children with malignancies and septic shock - an attempt to understand the risk factors
CONCLUSIONS: Recurrence of any cancer is an important risk of sepsis-related death. A positive fluid balance between 20 and 60 mL/kg or 2% and 6% of body weight in the first 24 hours after the onset of sepsis is related to lower mortality.PMID:36306822 | DOI:10.1016/j.jped.2022.09.003
Source: Jornal de Pediatria - October 28, 2022 Category: Pediatrics Authors: Rafael T Azevedo Orlei R Araujo Antonio S Petrilli Dafne C B Silva Source Type: research
Long‐Term Evaluation of Cardiac and Vascular Toxicity in Patients With Philadelphia Chromosome–Positive Leukemias Treated With Bosutinib
This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - March 11, 2016 Category: Hematology Authors: Jorge E. Cortes, H. Jean Khoury, Hagop Kantarjian, Tim H. Brümmendorf, Michael J. Mauro, Ewa Matczak, Dmitri Pavlov, Jean M. Aguiar, Kolette D. Fly, Svetoslav Dimitrov, Eric Leip, Mark Shapiro, Jeff H. Lipton, Jean‐Bernard Durand, Carlo Gambacorti‐Pa Tags: Research Article Source Type: research
Long‐term evaluation of cardiac and vascular toxicity in patients with Philadelphia chromosome‐positive leukemias treated with bosutinib
Vascular and cardiac safety during tyrosine kinase inhibitor (TKI) therapy is an emerging issue. We evaluated vascular/cardiac toxicities associated with long‐term bosutinib treatment for Philadelphia chromosome‐positive (Ph+) leukemia based on treatment‐emergent adverse events (TEAEs) and changes in QTc intervals and ejection fraction in two studies: a phase 1/2 study of second‐/third‐/fourth‐line bosutinib for Ph+ leukemia resistant/intolerant to prior TKIs (N = 570) and a phase 3 study of first‐line bosutinib (n = 248) versus imatinib (n = 251) in chronic phase chronic myeloid leukemia. Follow...
Source: American Journal of Hematology - April 12, 2016 Category: Hematology Authors: Jorge E. Cortes, H. Jean Khoury, Hagop Kantarjian, Tim H. Brümmendorf, Michael J. Mauro, Ewa Matczak, Dmitri Pavlov, Jean M. Aguiar, Kolette D. Fly, Svetoslav Dimitrov, Eric Leip, Mark Shapiro, Jeff H. Lipton, Jean‐Bernard Durand, Carlo Gambacorti‐Pa Tags: Research Article Source Type: research
Relationship Between State-Level Google Online Search Volume and Cancer Incidence in the United States: Retrospective Study
Conclusions: Cancer incidence is correlated with online search volume at the state level. Search patterns were temporally associated with cancer awareness months and celebrity announcements. Online searches reflect public awareness. Advancing understanding of online search patterns could augment traditional epidemiologic surveillance, provide opportunities for targeted patient engagement, and allow public information campaigns to be evaluated in ways previously unable to be measured.
Source: Journal of Medical Internet Research - January 8, 2018 Category: General Medicine Authors: Charles A. Phillips Allison Barz Leahy Yimei Li Marilyn M. Schapira L. Charles Bailey Raina M. Merchant Source Type: research
Is a Matched Unrelated Donor Search Needed for All Allogeneic Transplant Candidates?
ConclusionsRace, haplotype frequency and disease status at the time of MUD search influence probability to identify a MUD and receive a transplant. Patients with low likelihood to receive a MUD transplant may proceed to a haploidentical transplant as soon as indicated, as this approach does not appear to compromise transplant outcomes.DisclosuresKonopleva: Stemline Therapeutics: Research Funding. Oran: AROG pharmaceuticals: Research Funding; Celgene: Consultancy, Research Funding; ASTEX: Research Funding. Champlin: Otsuka: Research Funding; Sanofi: Research Funding.
Source: Blood - November 21, 2018 Category: Hematology Authors: Ciurea, S. O., Borges Bittencourt, M. C., Milton, D. R., Cao, K., Kongtim, P., Rondon, G., Chen, J., Konopleva, M. Y., Ramos Perez, J. M., Elshazly, M., Aljadayeh, M., Alvarez, M., Im, J. S., Alatrash, G., Mehta, R. S., Popat, U., Bashir, Q., Oran, B., Ho Tags: 732. Clinical Allogeneic Transplantation: Results: Poster II Source Type: research
